Presentation

Research objectives

The multidisciplinary research teams will explore the individual neurodevelopmental trajectories and underlying mechanisms of patients with neurodevelopmental disorders (NDDs), combining clinical and pre-clinical data.

• Defining individual trajectories
• Early identify, in each child, the key factor(s) responsible for abnormal brain development (genetic and environmental factors)
• Develop predictive biomarkers
• Develop individualised therapies

To achieve its objectives, I2-D2 & InovAND, based on the combined expertise of a unique consortium, use complementary approaches:

• Multimodal expert phenotyping of the patients with a database for the identification of specific common and individual trajectory traits in the NDDs.
• Biobanking for the search of predictive biomarkers.
• Use of preclinical models combined with human data (integrative omics) to understand underlying mechanisms.
• Search for therapeutic strategies for common traits and for individual care.

The close interaction between clinicians, clinical research structures, bioclinical laboratories, and translational researchers covering multiple aspects of NDDs (genetics, epigenetics, developmental neurobiology, neurosensory development, pharmacology, biomarkers, advanced imaging, and epidemiology) will promote a robust and unique continuum from bench to bedside.